Mechanisms of muscle weakness in muscular dystrophy
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چکیده
منابع مشابه
Mechanisms of muscle weakness in muscular dystrophy
Disruption of dystrophin or the sarcoglycans within the dystrophin protein complex leads to muscular dystro-phy. The dystrophin complex is enriched in myofibers and concentrated into costameres, rib-like structures in the plasma membrane. In the absence of dystrophin, the plasma membrane becomes fragile with reduced stiffness and increased leakiness, and exposing dystro-phin-deficient muscle to...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 2010
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.201010436